GLP-3 / Retatrutide
20mgRetatrutide (LY3437943) is a single-peptide triple agonist engineered to activate the GIP, GLP-1 and glucagon receptors, with a fatty acid side chain for extended activity. It is studied in receptor pharmacology assays that measure cAMP signaling and receptor selectivity, and in diet-induced obesity rodent models that track food intake, body composition and energy expenditure. Related work examines hepatic lipid handling and glucose homeostasis in the same models.
- GIP, GLP-1 and glucagon receptor signaling
- Energy balance and food intake models
- Glucose homeostasis
- Hepatic lipid metabolism
Models: Cell-based receptor assays; diet-induced obesity mice and rats
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