CJC-1295 (No DAC)
10mgCJC-1295 without DAC, also called Modified GRF (1-29), is a GHRH(1-29) analog with four amino acid substitutions that slow enzymatic breakdown by DPP-IV. The No DAC form lacks the drug affinity complex, so it has a much shorter circulating time than the DAC version in laboratory models. It is studied for GHRH receptor binding and cAMP signaling in pituitary cell cultures and for pulsatile growth hormone release in rodent models.
- GHRH receptor signaling
- Pulsatile GH release
- Peptide stability against DPP-IV
Models: Pituitary cell cultures; rodent models
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